Potensi Kombinasi Ekstrak Daun Mangga (Mangifera indica) dan Kulit Nanas (Ananas comosus) Jambi sebagai Antidiabetes Tipe 2 melalui Metode Enkapsulasi

Gita Aprilsa; Norita Simbolon; Feni Situmorang; Reva Meyliza; Delvina Jelita Putri; Yusnaidar Yusnaidar; Doni Lopian Hendri

doi:10.33096/jffi.v12i1.1382

Authors

Gita Aprilsa Prodi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author
Norita Simbolon Prodi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author
Feni Situmorang Prodi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author
Reva Meyliza Prodi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author
Delvina Jelita Putri Prodi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author
Yusnaidar Yusnaidar Prodi Kimia, Fakultas Sains dan Teknologi, Universitas Jambi Author
Doni Lopian Hendri Laboratorium Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jambi Author

DOI:

https://doi.org/10.33096/jffi.v12i1.1382

Keywords:

antioxidant, fractionation, Ipomoea carnea Jack, dpph method

Abstract

This study aims to develop a combination encapsulation preparation of mango leaf extract (Mangifera indica) and pineapple peel (Ananas comosus) as a candidate for diabetes treatment based on local natural ingredients from Jambi. Extraction was performed using the maceration method with 96% ethanol, yielding 91.33 grams of concentrated mango leaf extract and 50.19 grams of pineapple peel extract from 400 grams of dried crude drug each. Encapsulation was performed using a combination of maltodextrin and gelatin as coating materials through freeze drying at -53°C for 30 hours. The drying results showed the formation of a dark green encapsulation powder with a smooth and stable texture. In vitro antidiabetic activity testing using the DPPH method at a wavelength of 517 nm showed strong antioxidant activity, while in vivo testing was performed on male mice induced with alloxan with five treatment groups (normal, positive, negative, and a combination of 100 mg/kgBW and 300 mg/kgBW extracts). Glucose level testing was performed on days 3, 7, and 14. The results showed that the extract combination had the ability to significantly lower blood glucose levels compared to the other groups. This confirms that the encapsulation process can maintain the stability of bioactive compounds while increasing the effectiveness of the extract combination as a natural antidiabetic agent.

Downloads

Download data is not yet available.

References

Angelina, G. et al. (2021) “Enkapsulasi Serbuk Simplisia dan Ekstrak Kulit Jeruk Serta Aplikasinya Pada Vegetables Jam,” Jurnal Agroteknologi, 15(02), hal. 166–181. Tersedia pada: https://doi.org/10.19184/j-agt.v15i02.27358.

Arziyah, D., Yusmita, L. dan Wijayanti, R. (2022) “Analisis Mutu Organoleptik Sirup Kayu Manis Dengan Modifikasi Perbandingan Konsentrasi Gula Aren Dan Gula Pasir,” Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta, 1(2), hal. 105–109. Tersedia pada: https://doi.org/https://doi.org/10.47233/jppie.v1i2.602.

Astutisari, I.D.A.E.C., Darmini, A.A.. Y. dan Wulandari, I.A.P. (2022) “Hubungan Pola Makan Dan Aktivitas Fisik Dengan Kadar Gula Darah Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Manggis I,” Jurnal Riset Kesehatan Nasional, 6(2), hal. 79–87. Tersedia pada: https://doi.org/10.37294/jrkn.v6i2.350.

Chaudhary, M.N. et al. (2024) “Microencapsulation Efficiency of Carboxymethylcellulose, Gelatin, Maltodextrin, and Acacia for Aroma Preservation in Jasmine Instant Tea,” Gels, 10(670), hal. 1–14. Tersedia pada: https://doi.org/https://doi.org/10.3390/gels10100670.

Dutta, S. et al. (2023) “Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes,” Drug Design, Development and Therapy, 17, hal. 1907–1932. Tersedia pada: https://doi.org/10.2147/DDDT.S409373.

Fajrin, R. et al. (2025) “Enkapsulasi Antioksidan Ekstrak Kelopak Bunga Kecombrang (Etlingera Elatior) Menggunakan Maltodekstrin sebagai Matriks,” Jurnal Pertanian, 16(1), hal. 14–30.

Hestiana, D.W. (2017) “Faktor-Faktor yang Berhubungan dengan Kepatuhan Dalam Pengelolaan Diet Pada Pasien Rawat Jalan Diabetes Mellitus Tipe 2 Di Kota Semarang,” Jurnal of Health Education, 2(2), hal. 138–145.

Hisyam Adnan, M., Pratiwi, R.I. dan Sari, M.P. (2020) “Pengaruh Kombinasi Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) Dan Bengkoang (Pachyriuz erosus (L.) Urb) Terhadap Penurunan Kadar Gula Darah Pada Mencit Putih Jantan (Mus musculus),” Parapemikir: Jurnal Ilmiah Farmasi [Preprint]. Tersedia pada: http://ejournal.poltektegal.ac.id/index.php/parape.

Krismayadi et al. (2024) “Standarisasi Mutu Simplisia dan Ekstrak Etanol Daun Kemangi (Ocimum x africanum Lour.),” PHARMACY GENIUS, 03(02), hal. 67–81.

Mahardika, M. et al. (2023) “Sintesis dan Karakterisasi Cangkang Kapsul Non Gelatin dari Rumput Laut (Eucheumma cottonii) dan Kaktus Koboi (Cereus peruvianus) untuk Sistem Penghantaran Obat,” KOVALEN: Jurnal Riset Kimia, 9(1), hal. 1–12. Tersedia pada: https://doi.org/10.22487/kovalen.2023.v9.i1.16098.

Murisla, A.M. et al. (2025) “Potensi Aktivitas Antidiabetes Berbagai Jenis dan Varian Tanaman Mangga (Mangifera spp.),” Jurnal Riset Ilmu Kesehatan Umum dan Farmasi, 3(2), hal. 1–20. Tersedia pada: https://doi.org/https://doi.org/10.57213/jrikuf.v3i2.595.

Ngo, Dai-hung et al. (2019) “Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity,” Scientia Pharmaceutica, 87(13), hal. 1–12. Tersedia pada: https://doi.org/10.3390/scipharm87020013.

Nugraha, M.R. dan Hasanah, A.N. (2018) “Review Artikel: Metode Pengujian Aktivitas Antidiabetes,” Farmaka, 16(3), hal. 28–34.

Nurfitriyana, Fithri, N.A. dan Yanuarti, R. (2022) “Analisis Interaksi Kimia Fourier Transform Infrared (FTIR) Tablet Gastrorentif Ekstrak Daun PETAI (Parkia Speciosa Hassk) Dengan Polimer Hpmc-K4m Dan Kitosan” IONTech, 03(02), hal. 27–33.

Oktariani, E. et al. (2024) “Novel Finding of Pineapple Peel Extract as Antidiabetic Potential on Rats Induced With Streptozotocin,” JOPS: Journal of Pharmacy and Science, 7(2), hal. 126–134. Tersedia pada: https://scholar.google.com/citations?view_op=view_citation&hl=id&user=zEH3K10AAAAJ&citation_for_view=zEH3K10AAAAJ:eQOLeE2rZwMC.

Putri, M.A., Purwati, E. dan Safitri, C.I.N.H. (2021) “Formulasi dan Uji Mutu Fisik Sabun Padat Ekstrak Kulit Nanas (Ananas comosus L.),” Proceeding of Mulawarman Pharmaceuticals Conferences, hal. 275–281. Tersedia pada: http://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/416/399.

Ramadiansyah, B.A.G., Luketsi, W.P. dan Sari, M. (2020) “Uji Organoleptik Pada Fruit Leather Buah Nanas Subgrade Dengan Suhu Pengeringan Yang Berbeda,” Agroindustrial Technology Journal, 4(1), hal. 65–73. Tersedia pada: https://doi.org/10.21111/atj.v4i1.4322.

Saerang, M.F., Edy, H.J. dan Siampa, J.P. (2023) “Formulation Of Cream With Ethanol Extract Of Green Gedi Leaf (Abelmoschus manihot L.) AGAINST Propionibacterium acnes,” Pharmacon, 12(3), hal. 350–357.

Sari, D.P., Aditiyarini, D. dan Ariestanti, C.A. (2024) “Stabilitas Ekstrak Bunga Telang ( Clitoria ternatea L .) Terenkapsulasi Maltodekstrin dan Gelatin dan Potensi Prebiotiknya Stability of Encapsulated Butterfly Pea Flower ( Clitoria ternatea L .) Extract using Maltodextrin and Gelatin and Its Prebiotic Pot,” 9(3), hal. 226–237. Tersedia pada: https://doi.org/10.24002/biota.v9i3.7550.

Sasmita, M.A.D. (2021) “Faktor-faktor yang Mempengaruhi Tingkat Kepatuhan Berobat Pasien Diabetes Melitus,” Jurnal Medika Hutama, 2(4), hal. 1105–1111. Tersedia pada: http://jurnalmedikahutama.com.

Senduk, T.W., Montolalu, L.A.D.Y. dan Dotulong, V. (2020) “The rendement of boiled water extract of mature leaves of mangrove Sonneratia alba,” Jurnal Perikanan Dan Kelautan Tropis, 11(1), hal. 9–15. Tersedia pada: https://doi.org/10.35800/jpkt.11.1.2020.28659.

Tandi, E.A., Purwanti, R. dan Kemila, M. (2021) “Kadar Air Ekstrak Herba Sambiloto (Andrographis Paniculata) pada Variasi Suhu Pengeringan,” Jurnal Permata Indonesia, 12(1), hal. 1–6.